1.北京中医药大学东方医院,北京市丰台区方庄芳星园一区6号,100078
2.江苏省中医院
3.中国中医科学院西苑医院脾胃病研究所
通信作者:txdly@sina. com
收稿:2025-06-21,
修回:2025-11-20,
纸质出版:2026-01-02
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李军祥,沈洪,毛堂友等.炎症性肠病中医药诊疗及机制研究现状[J].中医杂志,2026,67(01):103-110.
LI Junxiang,SHEN Hong,MAO Tangyou,et al.Current Status of Traditional Chinese Medicine Diagnosis and Treatment of Inflammatory Bowel Disease and the Research on Mechanism[J].Journal of Traditional Chinese Medicine,2026,67(01):103-110.
李军祥,沈洪,毛堂友等.炎症性肠病中医药诊疗及机制研究现状[J].中医杂志,2026,67(01):103-110. DOI: 10.13288/j.11-2166/r.2026.01.016.
LI Junxiang,SHEN Hong,MAO Tangyou,et al.Current Status of Traditional Chinese Medicine Diagnosis and Treatment of Inflammatory Bowel Disease and the Research on Mechanism[J].Journal of Traditional Chinese Medicine,2026,67(01):103-110. DOI: 10.13288/j.11-2166/r.2026.01.016.
近年来中医药治疗炎症性肠病(IBD)取得了显著进展。全面检索2010年1月1日至2024年12月30日中国知网、万方数据知识服务平台、维普中文科技期刊数据库、中国生物医学文献服务系统等中文数据库,以及PubMed、Web of Science、Embase等英文数据库,系统梳理中医药在IBD临床诊疗及机制方面的研究文献。总结IBD中医病因病机研究的现状及临床实践创新认识及多元疗法(包括中药复方、单药/单体、针灸、中药灌肠、穴位贴敷等特色疗法),以及与西医常规治疗的协同增效作用。IBD的中成药研发与应用正呈现出从疗效验证向机制探索的深刻转变,中药治疗IBD疗效机制研究主要包括调节肠道菌群稳态、修复肠黏膜屏障、调节肠道免疫平衡方面。提出中医药诊疗IBD未来研究方向为中医诊疗模型的建立、拓展中医外治法与内治法的联合应用模式、创新针对个性化治疗方案、推进药物研发,旨在为IBD中医诊疗的规范化、精准化发展提供思路。
In recent years, traditional Chinese medicine (TCM) has achieved significant progress in the treatment of inflammatory bowel disease (IBD). A comprehensive literature search was conducted covering the period from January 1, 2010, to December 30, 2024, across Chinese databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP China Science and Technology Journal Database, and the Chinese Biomedical Literature Service System, as well as international databases such as PubMed, Web of Science, and Embase. The clinical applications and mechanistic studies of TCM in IBD were systematically reviewed. The current status of TCM research on the etiology and pathogenesis of IBD, innovative clinical practices, and multimodal therapeutic approaches, including Chinese herbal formulas, single herbs or active compounds, acupuncture, herbal retention enema, and acupoint application, were summarized, together with their synergistic effects when combined with western medical treatments. The development and application of Chinese patent medicines for IBD are undergoing a profound transition from efficacy validation to mechanistic exploration. Mechanistic studies on the effects of TCM in IBD mainly focus on regulating gut microbiota homeostasis, repairing the intestinal mucosal barrier, and modulating intestinal immune balance. Furthermore, future research directions for TCM-based IBD management are proposed, including the establishment of TCM diagnostic and treatment models, expanding integrated applications of external and internal TCM therapies, innovating personalized treatment strategies, and advancing drug development. These efforts aim to provide insights for the standardized and precision-oriented development of TCM in the diagnosis and treatment of IBD.
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