中国中医科学院广安门医院,北京市西城区北线阁5号,100053
通信作者:heqingyongg@163.com
收稿:2025-07-20,
修回:2025-11-01,
纸质出版:2026-02-17
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贾裕智,何庆勇,王阶等.基于“血水同病”理论探析经方叠用辨治射血分数保留的心力衰竭干预策略[J].中医杂志,2026,67(04):370-374.
JIA Yuzhi,HE Qingyong,WANG Jie,et al.Intervention Strategies for Heart Failure with Preserved Ejection Fraction Using Combined Classical Formulas Based on the Theory of "Disease of Both Blood and Water"[J].Journal of Traditional Chinese Medicine,2026,67(04):370-374.
贾裕智,何庆勇,王阶等.基于“血水同病”理论探析经方叠用辨治射血分数保留的心力衰竭干预策略[J].中医杂志,2026,67(04):370-374. DOI: 10.13288/j.11-2166/r.2026.04.005.
JIA Yuzhi,HE Qingyong,WANG Jie,et al.Intervention Strategies for Heart Failure with Preserved Ejection Fraction Using Combined Classical Formulas Based on the Theory of "Disease of Both Blood and Water"[J].Journal of Traditional Chinese Medicine,2026,67(04):370-374. DOI: 10.13288/j.11-2166/r.2026.04.005.
基于《金匮要略》“血水同病”理论,并结合射血分数保留的心力衰竭(HFpEF)动态证候演变规律,系统阐释HFpEF阳虚为本、血瘀为枢、水停为标的病机传变规律。提出温阳培元以固其本、活血通络以畅其机、利水调枢以祛其标的治则。构建了“一君一臣一佐”复方结构,形成温阳、活血、利水三法协同的整体干预策略,采用经方叠用方法,即真武汤温阳化饮固其本,直抵阳虚病源为君;桂枝茯苓丸活血利水通其枢,辅助阻断瘀水互结为臣;葶苈大枣泻肺汤行气散饮祛其标,缓解水饮急证为佐。该复方温而不燥,利而不峻,祛瘀而不耗血,共达温阳活血利水之功效。
Based on the theory of "disease of both blood and water" in
Essentials from the Golden Cabinet
(《金匮要略》), and in combination with the dynamic syndrome evolution of heart failure with preserved ejection fraction (HFpEF), this paper systematically clarifies the pathomechanism of HFpEF, characterized by
yang
deficiency as the root, blood stasis as the pivotal factor and water retention as the manifestation. Accordingly, the therapeutic principles have been proposed, which are warming
yang
and banking up original
qi
to consolidate the root, activating blood and unblocking col
laterals to smooth the mechanism, and promoting urination and regulating pivot to remove the branch. On this basis, a compound formula structure of "one monarch, one minister and one assistant" is established, forming an integrated intervention strategy that synergistically combines the three methods of warming
yang
, activating blood, and promoting urination through combined classical formulas.
Zhenwu Decoction
(真武汤), which warms
yang
and dissolves rheum, is used to consolidate the root and directly target the source of
yang
deficiency, serving as the monarch;
Guizhi Fuling Pills
(桂枝茯苓丸), which activates blood, promotes urination and unblocks the pivot, assists in interrupting the binding of blood stasis and water retention, serving as the minister;
Tingli Dazao Xiefei Decoction
(葶苈大枣泻肺汤), which regulates
qi
, disperses retained fluids, and eliminates the manifestation, alleviates acute water-retention symptoms, serving as the assistant. This compound formula is warming without being drying, diuretic without being drastic, and dispels stasis without consuming blood, thereby achieving the therapeutic effects of warming
yang
, activating blood, and promoting urination.
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