1.北京中医药大学第一临床医学院,北京市东城区海运仓胡同5号,100700
2.北京中医药大学东直门医院
3.北京中医药大学东方医院
4.国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院
fengli663@126.com
收稿:2025-09-15,
修回:2026-04-08,
录用:2026-02-14,
纸质出版:2026-05-02
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胡圣涓,侯丽,孙韬等.从“内风暗旋”辨治小细胞肺癌[J].中医杂志,2026,67(09):1003-1007.
HU Shengjuan,HOU Li,SUN Tao,et al.Differentiation and Treatment of Small Cell Lung Cancer from the Perspective of "Internal Wind in Hidden Circulation"[J].Journal of Traditional Chinese Medicine,2026,67(09):1003-1007.
胡圣涓,侯丽,孙韬等.从“内风暗旋”辨治小细胞肺癌[J].中医杂志,2026,67(09):1003-1007. DOI: 10.13288/j.11-2166/r.2026.09.013.
HU Shengjuan,HOU Li,SUN Tao,et al.Differentiation and Treatment of Small Cell Lung Cancer from the Perspective of "Internal Wind in Hidden Circulation"[J].Journal of Traditional Chinese Medicine,2026,67(09):1003-1007. DOI: 10.13288/j.11-2166/r.2026.09.013.
小细胞肺癌发病快、侵袭性高、易复发转移,符合风邪致病特点。从“内风暗旋”探讨小细胞肺癌的病机变化及动态辨治,认为其核心病机以正气亏虚为本,痰瘀毒相互胶结,病邪盛极、阳气升降乖戾而化风,内风暗旋,走窜伤正。局限期癌毒蕴结、内风暗生,治宜调气解毒、御风抗邪,以补肺汤合升降散加减;广泛期初始阶段痰瘀生风、内风窜络,治宜化痰祛瘀、熄风解毒,以羚角钩藤汤合天麻钩藤饮加减;治疗期气阴亏虚、虚风内扰,治宜益气滋阴、柔肝熄风,以镇肝熄风汤合清燥救肺汤加减;进展期内风再起、癌毒走窜,治宜扶正填精、敛风透毒,以三甲复脉汤加减;终末期阴阳离决、虚阳浮越,治宜敛涩固脱、回阳摄阴,以地黄饮子合来复汤加减。
Small cell lung cancer (SCLC) is characterized by rapid onset, high invasiveness, and a strong tendency for recurrence and metastasis, which aligns with the pathogenic characteristics of wind pathogen in traditional Chinese medicine (TCM). This paper explores the pathological mechanism and dynamic pattern identification and treatment of SCLC from the perspective of "internal wind in hidden circulation". It is proposed that the core pathogenesis of SCLC is rooted in depletion of healthy
qi
, with binding of phlegm,
stasis, and toxin. When pathogenic factors become excessive, the ascending and descending of
yang qi
becomes disordered, transforming into wind. This leads to internal wind in hidden circulation, which moves erratically and damages healthy
qi
. In the limited stage, cancer toxin accumulates and internal wind arises covertly, treatment for which should focus on regulating
qi
and resolving toxin, defending against wind and resisting pathogen with modified
Bufei Decoction
(补肺汤) and
Shengjiang Powder
(升降散). In the early extensive stage, phlegm and stasis generate wind, and internal wind spreads through collate-rals; treatment should resolve phlegm and dispel stasis, extinguish wind and resolve toxin, with modified
Lingjiao Gouteng Decoction
(羚角钩藤汤) combined with
Tianma Gouteng Beverage
(天麻钩藤饮). During the treatment stage, there is
qi
and
yin
depletion, and deficient wind harassing the interior, for which it is recommended to boost
qi
and nourish
yin
, soften the liver and extinguish wind, with modified
Zhengan Xifeng Decoction
(镇肝熄风汤) combined with
Qingzao Jiufei Decoction
(清燥救肺汤). In the progression stage, internal wind stirs again and cancer toxin scurries; treatment should focus on strengthening the healthy
qi
and replenishing essence, restraining wind and penetrating toxin, with modified
Sanjia Fumai Decoction
(三甲复脉汤). In the terminal stage,
yin
and
yang
are on the verge of dissociation and depleted
yang
floats upward; treatment should constrain and astringe to prevent collapse, rescue
yang
and contain
yin
, with modified
Dihuang Drink
(地黄饮子) combined with
Laifu Decoction
(来复汤).
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