杭州市中医院,浙江省杭州市体育场路453号,310007
xuelai0930@163.com
收稿:2025-10-27,
修回:2026-03-09,
录用:2026-01-14,
纸质出版:2026-05-17
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李亚楠,万政佐,董学亮等.经皮穴位电刺激对单侧双通道脊柱内镜手术患者应激反应的影响[J].中医杂志,2026,67(10):1071-1077.
LI Yanan,WAN Zhengzuo,DONG Xueliang,et al.Effect of Transcutaneous Electrical Acupoint Stimulation on Stress Response in Patients Undergoing Unilateral Biportal Endoscopy[J].Journal of Traditional Chinese Medicine,2026,67(10):1071-1077.
李亚楠,万政佐,董学亮等.经皮穴位电刺激对单侧双通道脊柱内镜手术患者应激反应的影响[J].中医杂志,2026,67(10):1071-1077. DOI: 10.13288/j.11-2166/r.2026.10.008.
LI Yanan,WAN Zhengzuo,DONG Xueliang,et al.Effect of Transcutaneous Electrical Acupoint Stimulation on Stress Response in Patients Undergoing Unilateral Biportal Endoscopy[J].Journal of Traditional Chinese Medicine,2026,67(10):1071-1077. DOI: 10.13288/j.11-2166/r.2026.10.008.
目的
2
探讨经皮穴位电刺激(TEAS)对单侧双通道脊柱内镜(UBE)手术患者应激反应的影响,并优化TEAS参数方案。
方法
2
选取拟行UBE手术的患者96例,随机分为全凭静脉麻醉组、针刺辅助麻醉连续波组和针刺辅助麻醉疏密波组,每组32例。各组患者均采用标准化全凭静脉麻醉方案,针刺辅助麻醉连续波组(100 Hz连续波刺激)和针刺辅助麻醉疏密波组(2/100 Hz疏密波刺激)在全凭静脉麻醉诱导前30 min于双侧足三里、三阴交穴位施加TEAS干预,持续至手术结束,全凭静脉麻醉组仅连接电极片不予通电。比较各组麻醉诱导前(T0)、气管插管后(T1)、椎板减压时(T2)、术毕1 h(T3)的应激反应指标[血清皮质醇(Cor)、促肾上腺皮质激素(ACTH)]和心率(HR)、平均动脉压(MAP)、脑电双频指数(BIS);比较手术时长、麻醉时长、拔管时长、苏醒时长,术后2 h、6 h、12 h的疼痛视觉模拟量表(VAS)评分、Ramsay镇静评分以及术后并发症发生情况。
结果
2
针刺辅助麻醉连续波组和针刺辅助麻醉疏密波组在T1、T2、T3时间点血清ACTH、Cor水平,在T1、T2时间点HR、MAP均低于全凭静脉麻醉组,且针刺辅助麻醉疏密波组上述指标低于针刺辅助麻醉连续波组(
P
<0.01)。针刺辅助麻醉疏密波组在T3时间点BIS高于全凭静脉麻醉组和针刺辅助麻醉连续波组(
P
<0.01)。各组手术时长比较差异无统计学意义(
P
>0.05);针刺辅助麻醉连续波组和针刺辅助麻醉疏密波组麻醉时长、拔管时长、苏醒时长均短于全凭静脉麻醉组,且针刺辅助麻醉疏密波组上述指标短于针刺辅助麻醉连续波组(
P
<0.05)。针刺辅助麻醉连续波组和针刺辅助麻醉疏密波组在术后2 h、6 h、12 h的VAS评分均低于全凭静脉麻醉组,且针刺辅助麻醉疏密波组各时间点VAS评分低于针刺辅助麻醉连续波组(
P
<0.05)。针刺辅助麻醉疏密波组Ramsay评分在术后2 h、6 h低于针刺辅助麻醉连续波组(
P
<0.05)。针刺辅助麻醉疏密波组并发症总发生率(6.25%,2/32)低于全凭静脉麻醉组(28.13%,9/32,
P
<0.05)。
结论
2
TEAS可有效抑制UBE手术患者的应激反应,其中2/100 Hz疏密波参数方案效果最优,其可稳定血流动力学,加速苏醒并改善术后镇静、镇痛质量,同时减少并发症发生。
Objective
2
To explore the effect of transcutaneous electrical acupoint stimulation (TEAS) on stress response in patients undergoing unilateral biportal endoscopy (UBE) and to identify optimal TEAS parameters.
Methods
2
A total of 96 patients undergoing UBE were randomly grouped into total intravenous anesthesia (TIVA) group, acupuncture-assisted anesthesia with continuous waves (AACW) group, and acupuncture-assisted anesthesia with sparse-dense waves (AASDW) group, with 32 patients per group. All groups were given a standardized TIVA protocol. In the AACW group (100 Hz continuous wave stimulation) and the AASDW group (2/100 Hz sparse-dense wave stimulation), TEAS intervention was applied to both bilateral Zusanli (ST36) and Sanyinjiao (SP6) 30 minutes before TIVA induction and continued until the end of the surgery. In the TIVA group, electrodes were only connected without electrical stimulation. The stress response indicators including cortisol (Cor) and adrenocorticotropic hormone (ACTH), heart rate (HR), mean arterial pressure (MAP), and bispectral index (BIS) at before anesthesia induction (T0), after tracheal intubation (T1), during laminectomy (T2), and 1 hour after surgery (T3) were compared across groups. The operation duration, anesthesia duration, extubation and recovery duration were recorded, as well as pain intensity including visual analogue scale (VAS), and sedation level (by Ramsay sedation score) at 2, 6, 12 hours after surgery, and postoperative complications.
Results
2
The AACW group and AASDW group had lower ACTH and COR levels at T1, T2 and T3, as well as lower HR and MAP levels at T1 and T2 than TIVA group, with AASDW group being lower than AACW group (
P
<0.05). At T3, the AASDW group had higher BIS than TIVA group and AACW group (
P
<0.05). No significant difference in operation duration was observed (
P
>0.05). The AACW group and AASDW group had shorter anesthesia, extubation and recovery duration than TIVA group, with AASDW group being the shortest (
P
<0.05). The VAS scores at 2 h, 6 h, and 12 h after surgery in the AACW and AASDW groups were lower than those in the TIVA group, with the AASDW group showing significa
ntly lower scores than the AACW group (
P
<0.05). The Ramsay sedation scores in the AASDW group were lower than those in the AACW group at 2 h and 6 h after surgery (
P
<0.05). The total incidence of complications in the AASDW group was 6.25% (2/32), significantly lower than 28.13% (9/32) in the TIVA group (
P
<0.05).
Conclusion
2
TEAS can effectively suppresses stress response in patients undergoing UBE, with the 2/100 Hz sparse-dense wave parameter being most effective, which can stabilize hemodynamics, accelerate recovery, improve postoperative sedation and analgesia quality, and reduces complications.
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