DAI Xinyi,ZHANG Jiaqi,SHE Meiling,et al.Prevention and Treatment of the Relapse of Ulcerative Colitis Based on the Theory of Damp-Heat Latent Pathogen[J].Journal of Traditional Chinese Medicine,2026,67(11):1231-1234.
DAI Xinyi,ZHANG Jiaqi,SHE Meiling,et al.Prevention and Treatment of the Relapse of Ulcerative Colitis Based on the Theory of Damp-Heat Latent Pathogen[J].Journal of Traditional Chinese Medicine,2026,67(11):1231-1234.DOI: 10.13288/j.11-2166/r.2026.11.016.
Aligning with the ulcerative colitis (UC) dynamic characteristics of latent pathogens, that is "remaining latent and concealed, and manifesting when triggered", and following the latent pathogen theory, it is proposed that the core pathogenesis of UC recurrence is latent damp-heat pathogen concealed internally, progressing from
qi
to blood level over time, and leading to
qi
-blood disharmony and intestinal collateral damage. Accordingly, stage-based treatment is recommended. During the active stage, it is suggested to clear damp-heat, move
qi
, and regulate blood using modified
Gegen Qinlian Decoction
(葛根芩连汤). During the remission stage, the treatment should focus on reinforcing healthy
qi
and venting pathogen, regulate and tonify the spleen and kidney with a self-made
Jianpi Qingchang Mixture
(健脾清肠合剂). These approaches may provide a reference for the clinical treatment of UC.
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references
LONG M D , RUBIN D T . Histologic remission in ulcera-tive colitis: are we there yet? [J]. Am J Gastroenterol , 2019 , 114 ( 5 ): 713 - 715 .
FUMERY M , SINGH S , DULAI P S , et al . Natural history of adult ulcerative colitis in population-based cohorts: a systematic review [J]. Clin Gastroenterol Hepatol , 2018 , 16 ( 3 ): 343 - 356 .