Based on Professor YANG Zhen's theory of "

qi

dynamics of ministerial fire"， this paper systematically elucidates the pathogenesis of

jueyin

（厥阴） disease and the clinical rationale for applying

Wumei Pill

（乌梅丸）.

Jueyin

disease is characterized by dysfunction of the middle earth in regulating

qi

dynamics and disruption of the pivot mechanism， leading to an upward disturbance of ministerial fire and an underlying pattern of deficiency-cold of true

yang

， thereby forming a state of cold and heat in complexity.

Wumei Pill

fully exerts the synergistic effects of sour-astringency， bitter-descending， and acrid-warm medicinals， reflecting the therapeutic principle of regulating the pivot mechanism and restraining the upward rebellion of ministerial fire， with the aim of returning fire to its source and restoring the circulation of

qi

. Based on the four-dimensional pathological evolution of

Jueyin

disease， namely disorder of pivot

qi

harmonization， failure of

ying

（营）-blood nourishment and containment， loss of

yin

sustenance and balance， and instabi-lity of ministerial fire， the paper systematically reveals the underlying logic of

Wumei Pill

in treating different diseases with the same therapeutic princi

ple. In addition， a clinical case of hemoptysis treated with modified

Wumei Pill

is presented， providing insights into its formulation principles and expanding its application in complex and refractory multi-system diseases.