TCM principle of cooling blood and supporting resistance as a concerted therapy with all - trans retinoic acid were applied in our hospital from 1992 -1997 for 68 cases of promyelocytic leukemia. The rate of remission was 94. 1 % （in 64 cases） with a duration of remission lasting 35 - 49 days. No obvious toxic and side effects and complications were observed. The duration of remission in the treatment group was obviously shorter and the remission rate was obviously higher than those of the group treated with alone. The side effect of increasing leukocytes of which can also be ameliorated by the treatment.