To explore the effect of Fu Zheng Hua Yu Fang and its ingredient （s ） on collagen production we cultured the astrocytes isolated from the dimethyl nitorsamine -induced rat fibrosis model in serum with the extract of the completeprescription and its ingredient （s） and observed their effect in treating the model rats. The ingredients included those for strengthening the body resistance

those for removing stasis

that of Cordyceps

that of Radix Salviae Miltiorrhizae and that of Radix Salviae Miltiorrhizae plus Cordyceps. The results showed that though inhibition of proliferation and activation of the astrocytes was found in all the groups

the effect of the extract of drugs for removing stasis was the strongest. Similarly

inhibition of production of collagen type I and expression of its mRNA was found in all the groups while the effect of drugs for strengthening the body resistance was the strongest. In treating the model rats

the complete prescription was the strongest in reducing the collagen deposition and hyproxyproline content. Combination of drugs for removing stasis with those for strengthening body resistance could further reduce the formation of collagen. The prescription proved to be a comprehensive one in inhibiting collagen production.