Objective: In order to approach to the therapeutic effect and safety of tri - combination method in treatment of intermediate and late rheumatoid arthritis .（RA）.Method: Oral administration of Bi De Zhi Tabelets

Chinese drug steam therapeutic instrument combined with Han Shi Bi Yu Shu spray skin - permeating method

and injection of Zheng Qing Feng Tong Ning into articular cavity were used for treatment of 50 cases of intermediate and late rheumatoid arthritis with Yang - deficiency and accumulation of pathogenic cold and phlegm as tri - combination group A; and oral administration of Bi De Qing Yin decoctinon

Chinese drug stem therapeutic instrument combined with Han Re Bi Yu An spray skin -permeating method

and injection of Zheng Qing Feng Tong Ning into articular cavity were used to treat 45 cases of rheumatoid arthritis with Yin - deficiency

retention of pathogenic heat

and accumulation of phlegm as tri -combination group B

and 43 cases treated with oral medication of indomethacin plus intermuscular injection of MTX ascontrol group. Results: The control and markedly effective rate and the effective rate for TCM main symptoms were respectively 74%

26% and 86%

14% in group A; 73%

27% and 87%

13% in the group B; 28%

47% and 23%

37% in the control group. There was very significantly difference as the group A

and the group B compared with the control group respectively （P<0. 01）. There was a very significant difference （P<0. 01） before and after treatment in the group A and the group B in clinical symptoms

signs

inflammation index

and blood sedimenation

reactive protein

titer of rheumatoid factor

IgG

IgM

C3 and hemoglobin. And there was . a significantly difference （P < 0. 01 orP < 0. 05） as they compared with the control group. It is indicated that the tri -combination method has an obvious therapeutic effect on rheumatoid arthritis at metaphase and can increase life quality of the patient at late stage with safety.