In order to investigate the effect of acupuncture on immunologic cytokines

insulin sensitivity and high blood coagulation state in the patient of type II diabetes mellitus

the patients were divided into control group （50 cases） treated with routine drugs and combined acupuncture group （52 cases） treated with acupuncture combined with routine drugs

Tumor necrosis factor -α （TNF-α） and interleukin - 6 （IL - 6） contents were determined with RIA

at the same time

changes of in vitro thrombosis length

platelet agglutination rate

fibrinogen

activated partial thromboplastin time

prothrombin time

fasting blood glucose were observed before and after treatment. Results indicated that in the combined acupuncture group

immunologic cytokines and the contents of blood coagulation indexes decreased significantly

and the levels of insulin sensitivity indexes increased （P<0. 05 and P<0. 01）

with statistically significant differences compared with the control group （P<0. 05 and P<0. 01）. It is suggested that mechanisms of acupuncture treating type II diabetes are possibly related with regulation of cytokines

reduction of insulin resistance

increase of insulin sensitivity and improvement of microcirculation.