心理应激对大鼠下丘脑、胃粘膜CRF基因表达的影响及中药干预的实验研究

李杰; 刘长江; 李庆和; 韩娟; 李慧吉; 武成

doi:10.13288/j.11-2166/r.2002.09.047

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心理应激对大鼠下丘脑、胃粘膜CRF基因表达的影响及中药干预的实验研究

更新时间：2021-11-22

- 心理应激对大鼠下丘脑、胃粘膜CRF基因表达的影响及中药干预的实验研究
- Experimewtal study of Effect of psychogenic stress on expression of CRF gene in hypothalamus and gastric mucosa of the rat and intervention of Chinese drugs
- 中医杂志 2002年第9期页码：699-700
- 作者机构：
  
  1. 天津中医学院
  2. 天津中医药研究院天津市南开区鞍山西道玉泉路88号,300193
- 作者简介：
- 基金信息：
  
  天津市自然科学基金（963608211）
- DOI：10.13288/j.11-2166/r.2002.09.047
  中图分类号： R285
- 纸质出版：2002
- 稿件说明：
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[1]李杰,刘长江,李庆和,韩娟,李慧吉,武成.心理应激对大鼠下丘脑、胃粘膜CRF基因表达的影响及中药干预的实验研究[J].中医杂志,2002(09):699-700+5.

Experimewtal study of Effect of psychogenic stress on expression of CRF gene in hypothalamus and gastric mucosa of the rat and intervention of Chinese drugs[J]. Journal of Traditional Chinese Medicine2002, (9): 699-700.
[1]李杰,刘长江,李庆和,韩娟,李慧吉,武成.心理应激对大鼠下丘脑、胃粘膜CRF基因表达的影响及中药干预的实验研究[J].中医杂志,2002(09):699-700+5. DOI： 10.13288/j.11-2166/r.2002.09.047.

Experimewtal study of Effect of psychogenic stress on expression of CRF gene in hypothalamus and gastric mucosa of the rat and intervention of Chinese drugs[J]. Journal of Traditional Chinese Medicine2002, (9): 699-700. DOI： 10.13288/j.11-2166/r.2002.09.047.

摘要

目的:从分子水平阐明情志致病的机制及药物干预作用。方法:采用逆转录多聚酶链反应（RT—PCR ）的分子生物学技术

观察大鼠束缚浸水后下丘脑及胃粘膜中促肾上腺皮质激素释放因子信使核糖核酸（CRFmRNA）表达

及具有理气降逆散结作用的中药复方心身1号干预作用的分子生物机制。结果:与正常组比较

模型组大鼠呈现气机紊乱证表现、胃内可见广泛性浅表性溃疡

下丘脑及胃粘膜出现CRFmRNA表达

而服心身1号的中药组大鼠胃内溃疡显著减少

CRFmRNA表达量明显降低。结论:证实气机紊乱证与CRF基因表达相关

心身1号具有改善上述指标的作用。

Abstract

Objective: To expound the mechanism of emotion inducing diseases and the intervening action of drugs from molecular level. Methods: RT - PCR was used to investigate expression of corticotropin releasing factor CRFmRNA in the hypothalamus and gastric mucosa

and molecular biological mechanism of the intervening action of compound Xin Shen No. 1 with action of regulating the flow of Qi. lowering the adverse flow of Qi. and dispersing accumulation of pathogen in the rat after fastening and immersing in water. Results: Compared with the normal group

the model group showed disturbance of functional activity of Qi in microscope

extensive and superficial ulcer in the stomach and expression of CRFmRNA in the hypothalamus and gastric mucosa. and the Xin Shen No. 1 treatment group showed a significant decrease in gastric ulcer and CRFmRNA expression. Conclusion: Confirm the correlation between disturbance functional activity of Qi and CRF gene expression. and Xin Shen No. 1 has action of improving the above -mentioned indexes.

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