To explore therapeutic action of the formula for supplementing Qi and activating blood circulation on early arteriosclerosis obliterans （ASO）. Methods: 90 cases of ASO were randomly divided into 2 groups and treated for 2 months

and changes of their clinical manifests

blood lipids

hemorheology. vascular endotheliocyte function and hemodynamics were investigated before and after treatment. Results: The clinical cured rate and the total effective rate in the treatment group were 61. 67% and 100% respectively

and 36. 67% and 93. 33% in the control group. The treatment group in therapeutic effect for main symptoms and signs was superior to the control group （P < 0. 01）. There were significant differences in triglyceride （TG）. high density lipoprotein-cholesterol （HDL-C ）

lower density lipoprotein-cholesterol（LDL-C） （P<0. 01） and serum total cholesterol （TC）. very lower density lipoprotein-cholesterol （VLDL-C）. apoprotein A1（ApoA1） and apoprotein B100 （ApoB100） （P<0. 05） before and after treatment. After treatment

the various indexes of hemorheology decreased significantly （P<0. 01）. and plasma thromboxane B2 （TXB2） and 6-keto-prostaglandin F1α （6-keto-PGF1α） restored to normal; plasma endothelin （ET-1） level decreased

nitric oxide （NO） increased （P < 0. 05） in the treatment group. TXB2 in the both groups and 6-keto-PGF1αin the control group were significantly different from those of the normal group （P<0. 01）. After treatment

in the treatment group the width of lumen and volume of blood flow in the posterior femoral and poplitead arteries increased

and the ankle/ humeral index increased significantly （P<0. 01）. Conclusion: Huang Qi Tong Mai Mixture can obviously improve clinical symptoms of early ASO. and also can regulate lipid metabolism

antagonize thrombosis and protect vascular endotheliacyte function.