Objective: To assess the action of Yiqi Ruangan Decoction on hepatic fibrosis. Methods: The hepatic fibrosis rat model was prepared by human serum albumin. The protective group was administrated intragastrically with Yiqi Ruangan Decoction twice daily

and the control group received intraperitoneal injection of hepatic stimulating factor twice daily

for 8 weeks. Results: Death rate for hepatic fibrosis rat decreased in both groups. Determination of hydroxyproline

HE staining. argentaffin and VG staining of the hepatic tissue indicated that hyperplastic degrees of hepatic fibrosis decreased in both groups

and there was no significant difference between groups. Conclusion: Yiqi Ruangan Decoction and hepatic stimulating factor have a similar action in prevention of hepatic fibrosis.