Clinical Observation on Protective Action of Xinmaitong Capsules on Survival Myocardium in the Patient of Acute Myocardiac Infarction[J]. Journal of Traditional Chinese Medicine2003, (8): 598-600.
Clinical Observation on Protective Action of Xinmaitong Capsules on Survival Myocardium in the Patient of Acute Myocardiac Infarction[J]. Journal of Traditional Chinese Medicine2003, (8): 598-600.DOI: 10.13288/j.11-2166/r.2003.08.022.
Objective: To study protective action of TCM complex prescription Xinmaitong Capsules on survival myocardium in the patient of acute myocardiac infarction (AMI). Methods: 46 cases of AMI who had successfully received PTCA operation were randomly divided into treatment group and control group with 20 cases in each. On the basis of routine treatment of AMI. 3 days before the operation
treatment group began to take Xinmaitong Capsules for I weeks. Nuclide resting myocardium development segment numbers
nuclide myocardium perfusion defect range score (ES) and nuclide myocardium perfusion defect severe extent cummulative scores (SS). as well as the level of blood vascular endothelial growth factor (VEGF) were investigated before and after treatment. Results: The varying rate of the resting myocardium development segment number from score 1 to 2 was58. 33% in treatment group
significantly higher than 53. 33% in control group (P<0. 05). and ES and SS in treatment group was significantly lower than those in control group (P<0. 05). VEGF levels of 3 days and one week after the operation in treatment group were significantly higher than those in control group (P<0. 05). Conclusion: Xinmaitong Capsules can promote metabolic activity of the survival myocardium and expression of blood VEGF
exerting positive protective action on ischemic myocardium in the patient of AMI. Chinese drug for supplementing Qi and promoting blood circulation is of action like blood vessel neogenesis activity . contributing to formation of neonatal vessels and establishment of collateral circulation in the infarction region.which plays an important role in improvement of low perfusion state in ischemic survival myocardium.