Intervenient Action of Jianxin Decoction on Serum Cytokines in the Patient of Congestive Heart Failure[J]. Journal of Traditional Chinese Medicine2004, (3): 186-187.
Intervenient Action of Jianxin Decoction on Serum Cytokines in the Patient of Congestive Heart Failure[J]. Journal of Traditional Chinese Medicine2004, (3): 186-187.DOI: 10.13288/j.11-2166/r.2004.03.020.
Objective: To investigate intervenient actions of Jianxin Decoction on serum level of tumor necrosis factor-a (TNF-a)
interleukin-6 (IL-6) and nitric oxide (NO) in the patient of congestive heart failure (CHF). Methods: 66 cases of CHF were randomized to trial group and control group. 33 cases in each. Control group received routine treatment and the trial group was treated by routine treatment plus Jianxin Decoction for 4 weeks. TNF-a. IL-6 and NO level and cardiac function before and after treatment were investigated. Results: After treatment
serum TNF-a. IL-6 and NO level in both groups were significantly decreased with the trial group decreased more significantly (P< 0. 05). and the cardiac function significantly improved (P<0. 05 or P<0. 01) with the trial group being superior to the control group. Conclusion: Jianxin Decoction can adjust level of cytokines and can prevent and reverse ventricular remodeling and improve cardiac function in the patient of CHF.