Objective: To introduce a series of study on Chinese drug Pugui Pill for treatment of hysteromyoma of stagnant heat type. Methods: Observation group （30 cases） were treated by Pugui Pill and control group （20 cases） were treated by Gongliuqing Capsule. Improvement of clinical symptoms and hemodynamics and therapeutic effects were investigated

and the mechanism was studied. Results: Pugui Pill could obviously improve clinical symptoms

reduce size of the hysteromyoma. improve characteristics of hemodynamics

and regulate expression of insulin-like growth factor binding protein-3 （IGFBP-3） and insulin-like growth factor （IGF-1） in blood. Conclusion: Pugui pill functions clearing heat

resolving mass

activating blood circulation by removing blood stasis and analgesia

and it has a definite therapeutic effect on hysteromyoma with a total effective rate of 83.3%.