Objective: To observe the levels of plasma TNF-α and NO effected by Qingjie Shenkangling and further explain the antirecurrence mechanism of Qingjie Shenkangling. Methods: 60 patients with FRNS were randomly divided into group A and B. Group B were used as the control groups. Prednisone was adopted inducing remission transplanting and tapering methods: T

?

was adopted 24 weeks methods; or CTX was took vein pulsion; Qingjie Shenkangling was given at 5g each time

t. i. d for totally a year. Results: The level of plasma TNF-α and serum NO of the cases with FRNS at recurrence were markedly higher than control groups （P

<

0. 01）. After completion of therapy

TNF-α and NO levels of group A returned to normal. After completion of therapy

level of Serum CHO

24h pro

ALB of the cases with FRNS were significantly different between the treatment group A and the treatment group B （P

<

0. 01） after treatment. Efficacy was significantly different between group A and group B （P

<

0. 01） after treatment. Conclusion: Qingjie Shenkangling has significantly better effects on treatment and prophylaxis of FRNS. It can decrease the levels of TNF-α

control the injury associated with TNF-α and NO.