Objective:To study on effect of Jiantai Liquid on progesterone receptor（PR）in the uterus at the nidation stage in the mouse with disturbance of blastocyst nidation.Methods:The gestational mice were randomly divided into a normal group

a model group and a Chinese drug group.Mifepristone was used for inducing disturbance of blastocyst nidation in the mice

which were interfered with Jiantai Liquid.At the eighth week of pregnancy

the mice were killed and morphological changes of the endometrium were observed

and PR expression in the uterus was detected with immunohistochemical method and PR and PRmRNA expressions were detected with Western blot and PT-PCR methods.Results:The endometrium showed maldevelopment in the model group and normal development in the Chinese drug group

similar to the normal group;the gland

the PR expression range and intensity of PR expression in the interstitial substance in the Chinese drug group increased as compared with the model group（P<0.05）

and with no significant difference as compared with the normal group（P>0.05）;expressions of PR protein and gene in the Chinese drug group were significantly higher than those in the model group（P<0. 05）

with no significant difference as compared with the normal group（P>0.05）.Conclusion:Jiantai Liquid can promote development of the endometrium and improves blastocyst nidation via regulating expressions of PR and PRmRNA in the uterus in the mice with disturbance of blastocyst nidation.