Objective:To observe therapeutic effect of Bushen Huoxue Oral Liquid plus metformin on polycystic ovarian syndrome（PCOS）. Methods:58 cases of PCOS with hyperinsulinemia and hyperandrogenemia were randomly divided into an experiment group and a control group.The experiment group（n=30）were treated by Bushen Huoxue Oral Liquid plus metformin

and the control group （n=28）by oral administration of metformin.Results:After treatment

level of serum testosterone

luteotropin and fasting insulin decreased significantly

the ratio of fasting blood sugar/fasting insulin and insulin sensitivity index increased（P<0.05）in both groups

and there was no significant difference between two groups（P>0.05）.The ovulation rate and the pregnancy rate were 70% and 56.7% in the experiment group

and 32.1% and 21.4% in the control group

respectively

with significant differences between two groups（P<0.01）.Conclusion:Metformin has obvious therapeutic effect on endocrine imbalance in patient of PCOS

and metformin combined with Chinese drugs for tonifying the kidney and activating blood circulation can significantly increase the ovulation rate and the pregnancy rate in the patient of PCOS.