Objective:To observe effects of Cuttle-Bone on blood inorganic phosphorus and parathyroid hormone（PTH）in patients of uremia in hemodialysis.Methods:74 cases of uremia in hemodialysis were randomly divided into a control group

a cuttlefish bone treatment group and a calcium carbonate treatment group.The control group did not take any conjugation agent of phosphorus. The cuttlefish bone treatment group were treated with oral administration of cuttlefish bone powder 3.0g in each meal and the calcium carbonate treatment group with chewing calcium carbonate tablets 1.5g in each meal.They all were treated for 3 months. Results:After treatment

blood inorganic phosphorus and PTH decreased（P<0.01 or P<0.05）and blood calcium increased（P< 0.05）in the cuttlefish bone treatment group as compared with the other two group;blood inorganic phosphorus and PTH decreased as compared with those before treatment（both P<0.05）;the decrease of blood inorganic phosphorus was better than that of the calcium carbonate group（P<0.05）and the decrease of PHT level was similar to that of the calcium carbonate group （P>0.05）

with less effect on blood calcium（P<0.05）.After treatment

blood inorganic phosphorus and PTH decreased significantly in the cuttlefish bone treatment group as compared with those in the control group（both P<0.01）.Conclusion: Cuttlefish bone as a conjugation agent of phosphorus can decrease blood inorganic phosphorus

so as to prevent and treat renal osteopathy.