慢性粒细胞白血病融合基因与中医分型探讨

张励; 魏艾红; 王伟; 黄世林; 杨英选; 康洁霓

doi:10.13288/j.11-2166/r.2006.04.032

您当前的位置：

首页 >

文章列表页 >

慢性粒细胞白血病融合基因与中医分型探讨

更新时间：2021-11-21

- 慢性粒细胞白血病融合基因与中医分型探讨
- Study on Relationship between of Fusion Gene and TCM Syndrome Classification in the Patient of Chronic Myelogenous Leukemia
- 中医杂志 2006年第4期页码：293-294
- 作者机构：
  
  1. 中国人民解放军第二一医院中医血液病研究所
  2. 中国人民解放军沈阳军区卫生人员训练基地
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.04.032
  中图分类号： R273
- 纸质出版：2006
- 稿件说明：
移动端阅览
[1]张励,魏艾红,王伟,黄世林,杨英选,康洁霓.慢性粒细胞白血病融合基因与中医分型探讨[J].中医杂志,2006(04):293-294.

Zhang Li, Wei Aihong, Wang Wei, et al. Study on Relationship between of Fusion Gene and TCM Syndrome Classification in the Patient of Chronic Myelogenous Leukemia[J]. Journal of Traditional Chinese Medicine2006, (4): 293-294.
[1]张励,魏艾红,王伟,黄世林,杨英选,康洁霓.慢性粒细胞白血病融合基因与中医分型探讨[J].中医杂志,2006(04):293-294. DOI： 10.13288/j.11-2166/r.2006.04.032.

Zhang Li, Wei Aihong, Wang Wei, et al. Study on Relationship between of Fusion Gene and TCM Syndrome Classification in the Patient of Chronic Myelogenous Leukemia[J]. Journal of Traditional Chinese Medicine2006, (4): 293-294. DOI： 10.13288/j.11-2166/r.2006.04.032.

摘要

目的:探讨慢性粒细胞白血病（CML）患者BCR/ABL融合基因表达与中医辨证分型的关系。方法:采用筑巢式RT-PCR方法

扩增30例CML患者BCR/ABL融合基因

从分子生物学角度探讨其与中医分型的关系。结果:气阴两虚型与瘀血痰结型患者BCR/ABL基因阳性率明显高于毒热炽盛型（P<0.01）

经过治疗后

瘀血痰结型BCR/ABL基因阳性率高于气阴两虚型（P<0.05）。结论:90%以上的CML患者都具有BCR/ABL融合基因的表达

该融合基因是实验室诊断指标之一

其表达与变化为指导CML中医辨证诊治提供了客观指标。

Abstract

Objective:To study on relationship between of BCR/ABL fusion gene expression and TCM syndrome classification in the patient of chronic myelogenous leukemia（CML）.Methods:Nest-building RT-PCR method was used for amplification of BCR/ABL fusion gene in 30 cases of CML

so as to explore the relationship between gene and TCM syndrome classification from the perspective of molecular biology.Results:The positive rate of BCR/ABL gene in the patient with both qi and yin deficiency

and the patient of intermingled phlegm and blood stasis was significantly higher than that in the patient of intense noxious heat type（P<0.01）.After treatment

the positive rate of BCR/ABL gene in the patient of intermingled phlegm and blood stasis was higher than that in the patient with both qi and yin deficiency（P<0.05）.Conclusion:Over 90% patients of CML have expression of BCR/ABL fusion gene

which is a laboratory index for diagnosis of CML

and its expression and changes are an objective index for guiding diagnosis and treatment of CML.

关键词

Keywords

references

查看原文

浏览量

156

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

初诊2型糖尿病患者中医辨证分型与PPARD-87C>T基因多态性的关系

胃癌中医证型与胃癌转移相关基因 E-cadherin 的关系研究

“天癸”与女性生殖遗传疾病相关性探究

真实世界研究视角下功能性消化不良-肠易激综合征共病随机对照试验的现状分析及对策建议

李果烈从“升清降浊”辨治直立性低血压经验