SHA Song-hua1, LI Guang-ming2, LIU Meng-lu2. Mechanism of Naoshang Lesheng Granule on Brain Injury[J]. Journal of Traditional Chinese Medicine2007, (2): 166-168.
SHA Song-hua1, LI Guang-ming2, LIU Meng-lu2. Mechanism of Naoshang Lesheng Granule on Brain Injury[J]. Journal of Traditional Chinese Medicine2007, (2): 166-168.DOI: 10.13288/j.11-2166/r.2007.02.041.
Objective To study the mechanism of Naoshang Lesheng Granule for brain injury.Methods SD rats were divided into different groups
and Naoshang Lesheng Granule (12g/kg
6g/kg
3g/kg) and Nimodipine (10mg/kg) were given respectively.Moisture capacity of brain
cerebral index
MDA
degree of cerebral infarction and injury condition of motor nerval function were observed.Healthy hybrid dogs of different groups were given Naoshang Lesheng Granule (3.0g/kg
1.5g/kg) and Nimodipine (10mg/kg) respectively.Cerebral blood flow (CBF) and cerebral vascular resistance (CVR) were observed.Results Naoshang Lesheng Granule could reduce moisture capacity of brain
cerebral index
MDA and area of cerebral infarction and improve motor nerval function of rats with cerebral ischemia and brain injury remarkably.It could improve CBF and reduce CVR of dogs obviously and had no effect on heart rate
blood pressure and ECG.Conclusion Naoshang Lesheng Granule has significant therapeutic effect for brain injury.