ObjectiveTo study the effect of Xiaozhi Hugan（dissolve fat and protect liver） Capsule on the expression of peroxisome proliferator-activated receptor-α（PPARα） of rat models with non-alcoholic fatty liver disease（NAFLD）.MethodsThe 32 male SD rats were randomized into 4 groups with 8 in each.The blank group was fed with normal feedstuff.The model group

observed group and control group were fed with high-fat feedstuff and injected tetracycline into abdominal cavity to make NAFLD models.One week later

the rats were treated with Xiaozhi Hugan Capsule and Dongbao Gantai Tablet（Compound Methionine and Choline Bitartrate Tablet） respectively.Six weeks later

all rats were killed.The hepatic PPARα mRNA expression was observed in the way of Reverse-Transcriptase（RT-PCR）.The pathologic changes of liver and the alanine aminotransferase（ALT）

aspartate aminotransferase（AST）

total cholesterin（TC）

and triglyceride（TG） were observed.The contents of free fatty acid（FFA）

malonyl-dialdehyde（MDA） and superoxide dismutase（SOD） in the liver homogenate of different groups were also measured.ResultsIn the observed group

the PPARα mRNA expression increased

level of serum ALT

AST

TC

TG and the FFA and MDA in the liver homogenate decreased

but SOD increased.The fatty degeneration of liver was relieved.The effect was better than that of control group.ConclusionXiaozhi Hugan Capsule can activate PPARα mRNA expression and hold back lipid peroxidation at the same time.Thus NAFLD is treated.