Objective To study the influence of herbal decoction Shuxin Yin（SXY）on platelet activation of rats and mice with a- cute myocardial ischemia in order to explain its possible mechanism for treating coronary heart disease.Methods The rat model with acute myocardial ischemia and the mice model with acute myocardial ischemia and reperfusion were established.The male SD rats and ICR mice

51 each

were randomized into 5 groups respectively:sham operation group

model group

low dose SXY group

high dose SXY group

ticlopidine groap.Made models and collected blood Sample after 30 days gastric infusion in succession.The flow cytome- try technique and the monoclonal antibody examination were adopted to test the mice platelet glycoprotein CD

62

P;the radioim- munoassay was used to test rat platelet aggregation rate（PAR）

fibrinogen（Fg）

thromboxane B

2

（TXB

2

）and 6-keto-PGF

1α

and their ratio.Results Shuxin Yin can

inhibit the high expression of CD

62

P of mice with acute myocardial ischemia and reperfusion

and de- crease PAR

Fg and TXB

2

/6-keto-PGF

1α

of rats with acute myocardial isehemia.Compared with the effect of ticlopidine

the differ- ence was not significant.Conclusion Shuxin Yin could effectively inhibiting platelet activation in rats anel mice with acute myocardial ischemia

and its effect in preventing and treating coronary heart disease might be related to the inhibition of platelet activation.