Objective To study the effect of Ganning Fang （Formula for soothing the liver） on portal hypertension of hepatic cirrhosis. Methods The 70 patients with portal hypertension of hepatic cirrhosis were randomized into treatment group and control group

with 35 in each. The changes of indices including diameter of portal vein （DPV）

diameter of splenic vein （DSV）

portal vein maximum velocity （PVX）

splenic vein maximum velocity （SVX）

portal vein flow volume （PVF）

splenic vein flow volume （SVF）

liver fibrosis index of hyaluronic acid （HA）

precollagen Ⅲ （PⅢ）

laminin （LN）

collagen type Ⅳ（CⅣ）

and scores of clinical symptoms before and after treatment were observed. Results In the treatment group

DPV

DSV

PVF

SVF

HA

CⅣ and the scores of clinical symptoms after treatment were evidently reduced （P<0.01）; compared with the control group after treatment

the PVF and SVF were evidently reduced （P<0.01）

and DSV

HA

CⅣ and scores of clinical symptoms were also evidently reduced （P<0.05）. Conclusion Ganning Fang can reduce the pressure of portal vein of hepatic cirrhosis.