Objective To discuss the influence and mechanism of Ziyin Qingxin Decoction （Decoction for replenishing Yin and clearing heart） on insulin resistance （IR）

adiponectin

leptin

and TNF-α of patients with the metabolic syndrome.Methods The randomly divided two groups took rosiglitazone 4mg once a day based on stopping the drugs affecting blood glucose and insulin functions and on the strict diet. In addition

the treatment group took Ziyin Qingxin Decoction. Blood pressure （BP）

blood lipid

blood glucose

IR

adiponectin

leptin and TNF-α before were observed and after treatment.Results The therapeutic effect of two groups was significantly different （P<0.05）. IR

leptin

TNF-α and adiponectin of the two groups were improved with a significant difference （P<0.05）. Compared with control group

the treatment group had a significant difference after treatment （P<0.05）. Adiponectin was negatively correlated to waist circumference

IR

and BP （P<0.05）

while leptin positively correlated to waist circumference

IR

and TG （P<0.05）. TNF-α was positively correlated to BP

IR index

and leptin （P<0.05）

while negatively correlated to adiponectin （P<0.05）.Conclusion The good effect of Ziyin Qingxin Decoction and rosiglitazone for metabolic syndrome may be related with the improvement of fat tissue in secreting adiponectin

leptin and TNF-α and the insulin resistance as well.