Objective To study the mechanism of Qingre Huashi Yiqi Huoxue Formulae （Formulae for clearing heat

dissolving damp

reinforcing qi and activating blood） for H.pylori associated gastric diseases. Methods The 70 C57BL/6 mice were randomly divided into 7 groups with 10 in each:normal group

model group

Chinese medicine high

medium and low dosage groups

western medicine group

and the combination of Chinese and western medicine group. Ampicillin combined with H.pylori gavage was adopted to produce H.pylori infected models. Four weeks later

all the groups were given correspondent treatment. The morphological and pathological changes of the gastric mucosa and the colonization of H.pylori in the gastric mucosa were observed after 2 weeks. ResultsThe Chinese medicine high and medium dosage groups and the combination of Chinese and western medicine group had a better effect in clearing H.pylori （P<0.05）

compared with the western medicine group

there was no significant difference in result （P>0.05）. The Chinese medicine high and medium dosage groups

western medicine group

and the combination of Chinese and western medicine group had a significant morphological changes （P<0.05）

the improvement in the Chinese medicine high dosage group was especially obvious. Conclusion Qingre Huashi Yiqi Huoxue Formulae are effective in clearing H.pylori and can relieve inflammation of gastric mucosa significantly.