Objective To observe the effect of modified Yiqi Huoxue Recipes（Recipes for reinforcing qi and activating blood） combined with methimazole for hyperthyroidism.Methods The 115 patients of hyperthyroidism up to the diagnostic criteria were randomized into a treatment group（n=65） treated with the self-made Yiqi Huoxue Recipes combined with methimazole and a control group（n=50） treated with methimazole.The course of treatment was 6 months.The follow-up was carried out one year after medication.The thyroid functions

improvement of clinical symptoms and untoward reactions of both groups were observed.Results The thyroid functions and clinical symptoms of two groups were significantly improved（P<0.01）.The effective rate of the treatment group was 92.3% while that of the control group 78.0%

the difference was significant（P<0.05）.The improvement in palpitation

irritability

aversion to heat

profuse sweating

insomnia

fatigue and the total score of TCM syndrome in the treatment group were significantly different from those of the control group（P<0.05）.But the occurrence of untoward reactions and relapse of hyperthyroidism of treatment group were significantly lower than those of control group（P<0.05）.Conclusion The effect of Yiqi Huoxue Recipes for hyperthyroidism is remarkable.The combination of Chinese and western medication is superior in therapeutic result.