Objective To evaluate the effect of Pingganjian Decoction （Decoction for liver diseases） on the non-alcoholic fatty liver diseases （NAFLD）.Methods Totally 105 NAFLD patients were randomized into a treatment group （54 cases） and a control group （51 cases）.The former was treated with Pingganjian Decoction while the latter treated with Fufang Yiganling Tablets and Zhibituo Tablets for 3 months.Changes in the symptoms scores

body mass index （BMI）

waist-hip ratio （WHR）

CT ratio of liver-spleen

homeostasis model assessment insulin resistance （HOMA-IR）

liver functions

uric acid and blood-fat before and after treatment were observed.Results After treatment

in the treatment group

the symptom score was significantly decreased

CT ratio of liver-spleen was significantly increased

and the level of HOMA-IR was decreased.Compared with those of the control group

the difference was significant （P<0.01 or P<0.05）.Conclusion The effect of Pingganjian Decoction on NAFLD is definite.Possibly it relates to the improvement of insulin sensitivity of target organs

the regulation of the disordered metabolism

and the decrease of liver fat deposition.