补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响

王运律; 韩惠杰; 刘敏; 胡琦; 夏乐敏; 张晓峰

doi:10.13288/j.11-2166/r.2010.04.013

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补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响

临床研究 | 更新时间：2021-11-17

- 补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响
- Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients
- 中医杂志 2010年51卷第4期页码：323-325
- 作者机构：
  
  上海市中医医院血液科
- 作者简介：
- 基金信息：
  
  上海市卫生局科研基金资助项目（2004L013A）
- DOI：10.13288/j.11-2166/r.2010.04.013
  中图分类号： R259
- 纸质出版：2010
- 稿件说明：
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[1]王运律,韩惠杰,刘敏,胡琦,夏乐敏,张晓峰.补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响[J].中医杂志,2010,51(04):323-325.

WANG Yunlǜ, HAN Huijie, LIU Min, et al. Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients[J]. Journal of Traditional Chinese Medicine2010, 51(4): 323-325.
[1]王运律,韩惠杰,刘敏,胡琦,夏乐敏,张晓峰.补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响[J].中医杂志,2010,51(04):323-325. DOI： 10.13288/j.11-2166/r.2010.04.013.

WANG Yunlǜ, HAN Huijie, LIU Min, et al. Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients[J]. Journal of Traditional Chinese Medicine2010, 51(4): 323-325. DOI： 10.13288/j.11-2166/r.2010.04.013.

摘要

目的探讨补肾颗粒治疗慢性再生障碍性贫血（CAA）的作用机制。方法将CAA患者分为中药组（60例）和环胞菌素A组（CsA组

16例）;中药组以补肾颗粒为主辨证治疗

CsA组以环孢菌素A为主治疗

疗程6个月

另设健康对照组20名

比较健康对照组与CAA各组治疗前后CD3+、CD3+CD28+、CD3+CD95+的表达水平。结果CAA各组治疗前CD3+、CD3+CD28+、CD3+CD95+的表达均较健康对照组高（P<0.05）

以肾阴虚型表达异常更甚。各组治疗后CD28表达下调

CD95表达上调。结论CAA患者T细胞CD28及CD95表达异常;补肾颗粒可能通过调节CD28及CD95水平调控CAA患者T细胞的异常激活和凋亡

从而促进造血功能恢复。

Abstract

Objective To study the mechanism of Bushen Granule （G ranule for rein forcing the kidney） for the treatment of chronic aplastic anemia （CAA）. Methods The CAA patients were divided into the herbal group （60 cases） treated mainly by Bu shen Granule with syndrome differentiation and the Cyclosporin A group （16 cases ） tr eated mainly by Cyclosporin A for 6 months. The healthy control group consisting of 20 healthy subjects was set up. The expressions of CD3 +

CD3+CD28+

and CD3+CD95+ of the healthy control groups were compared with the herbal group and the Cyclosporin A group. Results The expressions of CD3 +

CD3+CD28+

and CD3+CD9 5+ of the CAA groups were higher than those of the healthy control group （P<0.05）

especia lly in those who were of kidney yin deficiency syndrome. In the treated groups

the expression of CD28 was down-regulated while that of CD95+ was up-regula ted. Conclusion B ushen Granule is able to regulate the abnormally activated T cells and their apo ptosis through regulating the expressions of CD28 and CD95

thus the hematopoiet ic function is restored.

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