Objective To observe the antipyretic effect of Shanggan Granule（Granule for treating upper respiratory tract infection）in treatment of acute upper respiratory tract infection.Methods In this multi-centered controlled trial

433 cases of acute upper respiratory tract infection collected from 8 hospitals were diagnosed as wind heat syndrome

wind cold syndrome

syndrome of both wei and qi being diseased

syndrome of wind attacking the exterior（without significant manifestation of cold or heat）

and syndrome of wind attacking the exterior（with complicated manifestation of cold and heat）.All of them were treated with Shanggan Granule for 3 days

2 times a day.After a 3-day’s observation

the body temperature of the patients in 1h

2h

3h

4h

24h

48h

and 72h was measured to record the instant antipyretic effect and the cured time.Results The fever was reduced in 216 cases（49.88%）within 4h and cured in 413 cases（95.38%）within 72h after medication respectively.There is no statistically significant difference among all syndromes（P>0.05）.Conclusion Shanggan Granule can treat the acute upper respiratory tract infection effectively.