Objective To explore the correlation between human immunodeficiency virus（HIV） infection patients and human leukocyte antigen genotypes

and to evaluate the therapeutic effect of Aikeqing Capsule（Capsule for AIDS） on HIV infected persons.Methods Thirty-five HIV infected persons and fifty-one AIDS patients were collected.Of them

the HIV infected persons were administered Aikeqing Capsule while AIDS patients medicated with antiviral western medicine.The polymerase chain reaction-sequence specificity primer（PCR-SSP） technique was used to detect the HLA-B genotype of all patients.The Karnovsky score was applied to score the patients.The T lymphocyte subsets and routine blood test were observed.The risk factors of the effect of Aikeqing Capsule were analyzed.Results The CD4

CD8 and Th/Ts of Bw4Bw4 genotype of AIDS patients increased significantly after treatment

and the CD4 and Th/Ts of Bw4Bw6 genotype were also increased significantly（P<0.01）.The change of T cells of different genotypes of HIV infected persons after treatment was not statistically significant（P>0.05）.Aikeqing Capsule-effective group had significant increase in CD4

Karnovsky score

body weight

leukocytes

and lymphocyte absolute value in comparing with before treatment（P<0.05 or P<0.01）.Age was the main influential factor of Aikeqing Capsule’s effect.Conclusion The immune function recovery of those patients carrying HLA-Bw4Bw4 genotype was faster than that of those carrying other genotypes

indicating that genetic background can influence the progression of disease.Aikeqing Capsule may be more effective for those people under the age of forty.