Objective To observe the intervention effect and mechanism of Yiqi Qingre Formula（Formula for replenishing qi and clearing heat） on infection of helic obacter pylori（Hp） type Ⅰ.Methods Totally 100 male n ude mice were randomized into normal control group

model group

Huangqi（Astragalus membranaceus） group

Huangqin（Radix scutellariae） group

and Yiqi Qingre Formula group

20 in each.The normal control group and the model group were given normal saline

while the others groups were given the conresponding drug 0.2ml/10g respectively.On the fourteenth day

all mice except tho se of the normal control group

were given 108cfu/ml Hp liquid intragastrically

1.3ml for each day.At the end of the second week

they were killed and the p53 and bcl-2 expression of gastric mucosa was observed.Results The p53 and bcl-2 ex pression of gastric mucosa was significantly increased in nude mice with Hp type Ⅰ infection（P<0.01）

while it was markedly reduced in Huangqi group

Hua ngqin group

and Yiqi Qingre Formula group in comparing with the model group（P<0.05 or P<0.01）.Among the three midicated groups

Yiqi Qingre Formula group was the most effective one.Conclusion Yiqi Qingre Formula has an inhib itory effect on the p53 and bcl-2 expression of gastric mucosa in nude mice with Hp type Ⅰ infection.The functional mechanism of which is possibly that it controls apoptosis genes to r educe abnormal apoptosis rate and maintain normal cellular proliferation process

thus relieving Hp’s lesions to gastric epithelial cells.