Objective To observe the therapeutic and prognosis effect of Shenfu Injection [injection of Renshen（Radix et Rhizoma Ginseng） and Fuzi（Radix Aconiti Lateralis Praeparata）] on advanced acquired immune deficiency syndrome model rhesus.Methods Ten China rhesus were randomized into control group and treatment group

with 5 in each.Model were established with intravenous infusion of SIVmac239 virus strain.When models developed in advanced stage

the control group was given symptomatic treatment of conventional western medicine and the treatment group was given intravenous infusion of Shenfu Injection in addition

20ml each

once daily.Each treatment course lasted for 20 days with an interval of 3 days.Models were treated until died.The survival time

weight changes

mental status

clinical score

histopathological changes

T lymphcytel subset CD4+%

CD4+/CD8+ and viral load were observed.Results There was no significant difference in mortality rate

the CD4+% and CD4+/CD8+ between groups（P>0.05）.The survival time of the treatment group was longer than that of the control group

with a significant difference（P<0.05）.The viral load in the treatment group significantly decreased as compared with the control group（P<0.05）.The differences of feeding situation

mental activities and the total score were statistically significant between groups（P<0.01）.Conclusion Shenfu Injection is effective for advanced AIDS model rhesus in prolonging the survival time

alleviating the clinical symptoms

delaying the disease progression speed and improving the haematological indices.