帕病2号方对肝肾不足型早期帕金森病中医证候的影响

雒晓东; 文晓东; 连新福; 王春玲

doi:10.13288/j.11-2166/r.2013.01.005

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帕病2号方对肝肾不足型早期帕金森病中医证候的影响

临床研究 | 更新时间：2021-11-17

- 帕病2号方对肝肾不足型早期帕金森病中医证候的影响
- Effect of Formula Ⅱ for Parkinson’s Disease on the TCM Syndrome of Early Parkinson’s Disease Patients with Liver-Kidney Deficiency Syndrome
- 中医杂志 2013年54卷第1期页码：32-34
- 作者机构：
  
  1. 广州中医药大学第二附属医院
  2. 广西中医药大学附属瑞康医院
  3. 广西中医药大学
- 作者简介：
- 基金信息：
  
  “十一五”国家科技支撑计划重大项目（2006BAI04A11-1）
- DOI：10.13288/j.11-2166/r.2013.01.005
  中图分类号： R277.7
- 纸质出版：2013
- 稿件说明：
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[1]雒晓东,文晓东,连新福,王春玲.帕病2号方对肝肾不足型早期帕金森病中医证候的影响[J].中医杂志,2013,54(01):32-34.

LUO Xiaodong1, WEN Xiaodong2, LIAN Xinfu1, et al. Effect of Formula Ⅱ for Parkinson’s Disease on the TCM Syndrome of Early Parkinson’s Disease Patients with Liver-Kidney Deficiency Syndrome[J]. Journal of Traditional Chinese Medicine2013, 54(1): 32-34.
[1]雒晓东,文晓东,连新福,王春玲.帕病2号方对肝肾不足型早期帕金森病中医证候的影响[J].中医杂志,2013,54(01):32-34. DOI： 10.13288/j.11-2166/r.2013.01.005.

LUO Xiaodong1, WEN Xiaodong2, LIAN Xinfu1, et al. Effect of Formula Ⅱ for Parkinson’s Disease on the TCM Syndrome of Early Parkinson’s Disease Patients with Liver-Kidney Deficiency Syndrome[J]. Journal of Traditional Chinese Medicine2013, 54(1): 32-34. DOI： 10.13288/j.11-2166/r.2013.01.005.

摘要

目的评价帕病2号方对肝肾不足型早期帕金森病中医证候的影响。方法将60例早期帕金森病患者随机分为帕病2号方组、美多巴组各30例。帕病2号方组采用中药帕病2号方治疗

每日1剂

分2次服用;美多巴组给予美多巴片治疗

每次62.5mg

每日2次

逐渐增量至每次250mg

每日3次。两组均治疗3个月后评价中医证候疗效

并于治疗前后进行中医证候评分。结果帕病2号方组中医证候疗效总有效率为89.66%

美多巴组总有效率为17.86%

两组比较差异有统计学意义（P<0.01）。帕病2号方组患者治疗后震颤、肢体拘挛、运动迟缓、头晕、失眠多梦、腰膝酸软、大便秘结评分均较治疗前降低（P<0.05或P<0.01）;治疗后两组患者震颤、头晕、失眠多梦、腰膝酸软、大便秘结评分差异有统计学意义（P<0.05或P<0.01）。结论帕病2号方能明显改善肝肾不足型早期帕金森病中医证候

在证候疗效方面明显优于美多巴。

Abstract

Objective To evaluate the effect of Formula Ⅱ for Parkinson’s Disease on the TCM syndrome of early Parkinson’s disease patients with liver-kidney deficiency syndrome.Methods Sixty cases of early Parkinson’s disease were randomized into the Formula Ⅱ for Parkinson’s Disease group and Madopar group

with 30in each.The Formula Ⅱ for Parkinson’s Disease group was given one dose of Formula Ⅱ for Parkinson’s Disease

twice daily.The Madopar group was given Madopar Tablets from 62.5mg each time

twice daily to 250mg each time

three times daily.The treatment course lasted for 3 months.The TCM syndrome was scored and the therapeutic effect of TCM syndrome was evaluated after treatment.Results The total effective rate of the FormulaⅡfor Parkinson’s Disease group and Madopar group was 89.66%and 17.86% respectively

with significant difference between groups（P<0.01）.The scores of tremor

hypertonicity of the limbs

bradykinesia

dizziness

insomnia

weak waist and constipation were significantly decreased in the Formula Ⅱ for Parkinson’s Disease group after treatment（P<0.05or P<0.01）.There were significant differences between groups in the scores of tremor

dizziness

insomnia

weak waist and constipation after treatment（P<0.05or P<0.01）.Conclusion Formula Ⅱ for Parkinson’s Disease can obviously improve the TCM syndrome of early Parkinson’s disease with liver-kidney deficiency syndrome

with better therapeutic effect of TCM syndrome than Madopar.

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