Objective To research the laws and changes of TCM therapy and medication for epidemic warm diseases based on literature. Methods The concept

therapy and prescription of epidemic warm diseases in medical books from Ming and Qing Dynasties to Republican Period were collected and compared with the literature in currentlypublished journals to explore the development in modern research. Results The nourishing-yin and protecting-fluid therapy

avoiding diaphoresis in wind-warm syndrome

mo yuan（ interpleuro-diaphramatic space） diffusion method

Yinqiao Powder and Sangjiu Drink established in the Ming and Qing Dynasties were still recognized and adopted in clinic nowadays. The timing of cooling and dissipating the blood and medication contraindications such as Chaihu（ Radix Bupleuri） robbing liver yin and other views proposed by Ming-Qing doctors were different from the modern literature. The prescriptions made in the Ming and Qing Dynasties such as Ganlu Xiaodu Micropills had been widely used in modern clinic. The research on formulation

composition and mechanism had been conducted as well. Conclusion The therapies and prescriptions for epidemic warm diseases made in the Ming and Qing Dynasties have been adopted and widely used in modern clinic. However

some theories are disputed or neglected in modern and are worthy of further study.