Objective To analyze ZHANG Binghou’s medication experience in treating chronic glomerulonephritis（ CGN） by data mining. Methods The prescribing information on 80 patients（ 252 visits） in specialist clinic of ZHANG Binghou was selected. The Case Report Form was designed

information was collected and the database was established. The frequency

effectiveness

medicinal property

flavors and channel entry of herbs were analyzed. The hierarchical cluster was performed with the longest-distance method after quantifying the nature

flavor and channel entry of commonly used herbs. Results Totally 232 herbs（ 4272 frequencies） were used in 80 CGN patients. There were 33 herbs with a frequency higher than 10%. The top 5 herbs were Shudihuang（ Radix Rehmanniae Praeparata

熟地黄）

Guijia（ Carapax et Plastrum Testudinis

龟甲）

Shiwei（ Folium Pyrrosiae

石韦）

Tufuling（ Rhizoma Smilacis Glabrae

土茯苓） and Chaobaizhu（ Atractylodis Macrocephalae Rhizoma Frictum

炒白术）. The deficiency-supplementing herbs

heat-clearing herbs

as well as water-disinhibiting and damp-percolating herbs were commonly used. The most frequently used herbs were with plain nature（ 36. 36%）

sweet flavor（ 78. 79%） and entry into kidney channel（ 48. 48%）. The clinical significance was clear when 33 herbs were clustered into 8 categories according to their nature. Conclusion Prof. ZHANG Binghou often uses herbs with plain or cold nature and sweet or bitter flavor to treat CGN according to kidney-supplementing spleen-strengthening therapy and heat-clearing dampness-disinhibiting and detoxication therapy.