Chronic heart failure is the end stage of a variety of cardiovascular diseases.To improve the clinical efficacy is difficult.Collateral Theory and Ying-Wei（nutrient qi and defensive qi）Theory can provide theoretical guidance for researching TCM pathogenesis and intervention of chronic heart failure and establishing treating principles and Qili Qiangxin Capsules.Both basic studies and clinical evidence-based studies have confirmed the intervention characteristics and exact efficacy of Qili Qiangxin Capsules.The combination of basic studies and clinical evidence-based studies guided by TCM theory can provide a new idea for innovating medicine research.