The problems in ideas and methodologies in syndrome studies such as the nature of syndrome and specific micro indicators

researching nature of syndrome under the framework of disease and syndrome

standardization of syndrome diagnosis and the introduction of systems biology in more than 50 years were reviewed with a reflection.Both the syndrome information and physiological and pathological information of molecules

cells and tissues are not the essence of TCM syndrome. The modernization of TCM syndrome should be based on the basic theory and thinking of TCM. The relationship between phenomena and nature should be paid great attention in the research of syndrome nature. The identification of TCM basic pathogenesis should be carried out firstly.