The article introduces academic thoughts of GUO Shikui. Combined with modern medical knowledge

Prof. GUO Shikui put forward the core of pathogenesis of coronary heart disease angina pectoris pathogenesis lay in"Qi-stagnation and blood stasis"and "hypofunction of Yang-Qi in chest"on the basis of extensively reading all previous dynasties ancient documents of traditional Chinese medicine. He firstly clearly used important therapeutic principle such as"promoting blood circulation to remove blood stasis"

"aromatic herbs activating yang"and so on to prevent and treat coronary heart disease

and has formed one whole set of prevention and treatment theory to coronary heart disease. He emphasized that treating cardiovascular disease should combine traditional Chinese and western medicine

and traditional Chinese medicine should combine differentiation of disease with differentiation of syndrome.In the long-term medical practice

Prof. GUO Shikui carried out a large number of clinical and basic researches aiming at the therapy of promoting blood circulation to remove blood stasis to prove the effectiveness of this therapy from the angle of modern medicine. Also he developed a variety of effective drugs such as "coronary heart Ⅱ"（ 冠心Ⅱ号）

"widen chest pill"（ 宽胸丸） and "widen chest aerosol"（ 宽胸气雾剂） to treat cardiovascular diseases

that has produced important influences on cardiovascular disease treatment in recent decades.