Objective Replicate dynamic evolution process of rat models with heart blood stasis syndrome and make prescriptions and syndromes verification. Methods Models of 3 stages were established adopting the combined method of high fat feeding and ligation of left anterior descending branch of coronary. Pre-blood stasis syndrome model was at the first stage. Sub-blood stasis syndrome model was at the second stage. Heart blood stasis syndrome model was at the third stage. Model control group

sham operation group

positive drug intervention control group and negative drug intervention control group were also established

with 8 rats in each group. After modeling successfully

rat models were verified by applying positive and negative drug intervention method. Rats of positive drug intervention control group and negative drug intervention control group were given solution of Yangxin Tongmai Tables（ 养心通脉片） 3. 25 g /（ kg·d） and Sini San（ 四逆散） 3. 00 g /（ kg·d）

respectively through gavage after modeling at the stage of heart blood stasis syndrome. Rats of heart blood stasis syndrome stage group were given purified water（ 1 ml /100 g） through gavage for 7 days. Rats ’ characterization scores of Chinese Medicine in each group were observed.Hemorheological indexes and blood lipid levels were detected. Results The characterization scores of Chinese medicine in pre-blood stasis syndrome stage group

sub-blood stasis syndrome stage group and heart blood stasis syndrome stage group were higher than those in corresponding control groups（ P < 0. 05）. Blood lipid levels in heart blood stasis syndrome stage group and sub-blood stasis syndrome stage group were higher than those in corresponding control groups（ P < 0. 05）. Serum viscosity level in pre-blood stasis syndrome stage group and sub-blood stasis syndrome stage group was higher than that in corresponding control groups（ P < 0. 05）. Compared with plasma viscosity and medium of whole blood viscosity

positive drug intervention control group was lower than negative drug intervention control group and heart blood stasis syndrome stage group（ P < 0. 05）. Conclusion Experimental animal models of heart blood stasis syndrome dynamic evolution process were preliminarily established by 3 stages modeling method and prescriptions and syndromes verification.