Objective To observe the clinical effect and safety of optimized New Shengmai Powder and original New Shengmai Powder treating chronic heart failure（ CHF） patients of blood stasis and fluid retention syndrome.Methods The study was a crossover randomized controlled trial with individual patient. Twenty patients were randomized into groups and given standard treatment of optimized New Shengmai Powder combined with western medicine

western medicine alone and original New Shengmai Powder combined with western medicine respectively according to different order for 4 weeks in every stage. After Chinese medicine treatment

a washout period of 2 weeks was added and western medicine alone was applied during the period. When analyzing trial results

researchers named the20 patients in the stage of western medicine alone as treatment control group

the 20 patients in the stage of original New Shengmai Powder as treatment original prescription group and the 20 patients in the stage of optimized New Shengmai Powder as treatment optimization group. Observed cardiac functional grading

scores of Chinese medicine symptoms

scores of life quality

6-miniutes walk distance and indexes of ultrasound cardiogram before treatment and at the end of 3 treatments. Results After treatment

total effective rate of cardiac functional grading effect of control

original prescription and optimization groups was 50. 0%

60. 0% and 85. 0% respectively. Optimization group was superior to original prescription and control groups（ P < 0. 05 or P < 0. 01）. After treatment

total score of Chinese medicine symptoms and item scores of shortness of breath

weakness and edema of face and limbs of optimization group were superior to those of original prescription group（ P < 0. 05）. After treatment

quality of life

6-miniutes walk distance and ultrasound cardiogram ejection fraction of original prescription and optimization groups were improved（ P < 0. 05 or P < 0. 01）; optimization group was superior to original prescription group（ P < 0. 05）.Conclusion Optimized New Shengmai Powder treating CHF was effective and safe. It was also better than original New Shengmai Powder in relieving clinical symptoms

improving quality of life

increasing 6-miniutes walk distance and ejection fraction.