Objective To study the effect and possible functional mechanism of Xiangbin Fang（香槟方） on gastrointestinal dysfunction after abdominal operation. Methods Exploratory laparotomy was performed on beagle.Stress sensors were implanted in antrum

pylorus

duodenum

jejunum and colon serosa to record gastrointestinal motility of dogs. Stomach fistula was installed in the gastric body for perfusing Xiangbin Fang. Chronic venous cannula was inserted in internal jugular vein for collecting blood and injecting medicine. The effect of Xiangbin Fang on gastrointestinal migrating motor complex（ MMC） during the period of interdigestive（ limosis） and digestion（ food taking） after operation

the effect of Xiangbin Fang on concentration of ghrelin in plasma after exploratory laparotomy

and the antagonistic effect of atropine and tetrodotoxin on Xiangbin Fang were observed. Results The amplitude index of antrum

pylorus

duodenum

jejunum and colon

and concentration of ghrelin in plasma of dogs in the operation group on the 0th

1st

2nd

and 3rd day after operation remarkably decreased compared with that in the control group（ P<0. 05 or P<0. 01）; The amplitude index in each part and concentration of ghrelin in plasma of dogs in the Xiangbin Fang group remarkably increased compared with that in the exploratory laparotomy group（ P<0. 05）.During the period of digestion

the amplitude index in each part of dogs after giving medicine on the 1st

2nd

and3 rd day after operation remarkably increased compared with that before giving medicine（ P<0. 01）. The amplitude index in each part of dogs remarkably increased after giving medicine compared with that after operation（ P<0. 01）.The amplitude index in each part of dogs after perfusing atropine and tetrodotoxin intravenously remarkably decreased compared with that after operation and giving Xiangbin Fang（ P<0. 01）. Conclusion Xiangbin Fang could remarkably improve gastrointestinal motility fading situation of dogs after abdominal operation. Its function may be by being mediated by releasing of endogenous Ghrelin and cholinergic neuron of enteric nervous system.