Objective To observe the effects and possible mechanism of Wangshi Lianpo Decoction（ 王氏连朴饮）on acute lung injury. Methods A total of 36 SD rats were randomly divided into control group

model group

dexamethasone group and Wangshi Lianpo Decoction high

middle and low dose groups

with 6 rats in each group

half male and female. The rats were given intragastric administration for 5 days before modeling

and the dexamethasone group was intragastrically administered with dexamethasone injection（ 0. 9 mg/ml）. The concentration of the high

middle and low doses groups were given 1. 75

0. 87

0. 43 g/ml Wangshi Lianpo Decoction

and the control group as well as the model group were orally administered with the same amount of distilled water once a day

1 ml each time.On the 6 th day

a model of acute lung injury was established after tail-end injection of endotoxin（ LPS） and was allowed to stand for 24 hours. On the 7 th day

the levels of tumor necrosis factor-α（ TNF-α） and interleukin-1β（ IL-1β） in the serum of rats were detected

and the histopathological state of lung and intestine was observed by HE staining. Results The expressions of TNF-α and IL-1β in serum of ALI model group were significantly increased（ P <0. 01）. Compared with the model group

serum TNF-α levels in the dexamethasone group and all Wangshi Lianpo Decoction groups were significantly decreased

and serum IL-1β levels were decreased in the dexamethasone group and Wangshi Lianpo Decoction high and middle dose groups（ P < 0. 01）. Compared with Wangshi Lianpo Decoction lowdose group

the serum TNF-α content of Wangshi Lianpo Decoction high-dose group was significantly decreased

and the serum IL-1β content of Wangshi Lianpo Decoction high and middle dose groups was also decreased（ P < 0. 01）.HE staining showed that the high

middle and low doses of Wangshi Lianpo Decoction had improved the lung and intestine tissues of ALI rats. The most remarkable effect occured in the high dose Wangshi Lianpo Decoction group.Conclusion Wangshi Lianpo Decoction has a certain protective effect on lung and intestinal tissues of rats with acute lung injury

and may inhibit the intestinal lung axis metastasis by controlling the inflammatory response.