Objective To analyze the difference of mechanism between traditional Chinese medicine（TCM） prescription and antiviral western medicine in the treatment of mild influenza

and to explore the possible mechanism of TCM compound anti-influenza virus. Methods Yinqiao Powder（银翘散） combined Modified Sangju Decoction（桑菊饮） and Modified Maxing Shigan Decoction（麻杏石甘汤） were selected to compare with oseltamivir

zanamivir and peramivir. In the biological database such as Sym Map

the target proteins of the drugs in the two TCM prescriptions were respectively searched

and the disease genes of the influenza in the disease gene pool were matched. The String database and Cytoscape software was used to interact and topologically analyze the target proteins

and the DAVID database was used to conduct enrichment analysis of the modules with high scores of the two TCM prescriptions

so as to clarify the biological mechanism of the two TCM compounds in the treatment of influenza mild disease. Results The target proteins of the included 3 western medicines were all neuraminidase

and the KEGG pathway involved sugar degradation process. There were 436 influenza genes

261 biological processes and 125 KEGG pathways in the target protein of Yinqiao Powder combined Modified Sangju Decoction. The target protein of Modified Maxing Shigan Decoction involved 464 influenza genes

262 biological processes

and 115 KEGG pathways. Except for a large number of same genes and signaling pathways

Yinqiao Powder combined Modified Sangju Decoction had the unique genes SIRT1

CAT and Th17 cell differentiation

T cell receptor signaling pathway and neurotrophin signaling pathway; Modified Maxing Shigan Decoction only had the unique genes CDKN1 B

LEP. Conclusion Compared with antiviral western medicine

the two TCM prescriptions regulate the human body through multi-target and multi-channel

and its function is more focused on improving the immunity of the human body and promoting the host’s own anti-infective ability.