Objective To explore the commended users

the dosage and treatment course of Antivirus Oral Liquid（抗病毒口服液） in the treatment of common cold in adult population. Methods A multicenter

randomized

double-blind

placebo-controlled clinical trial was adopted and patients were randomly divided into 1986 cases in the test group and 661 cases in the control group. Doses of 10 ml

20 ml and 30 ml were used as the stratification factor

and the test group were divided into 671 cases in the 10 ml test group

667 cases in the 20 ml test group and 648 in the 30 ml test group. The control group was divided into 220 cases in the 10 ml control group

222 cases in the 20 ml control group and 219 cases in the 30 ml control group. Each dose group of the test group took the corresponding dose of Antivirus Oral Liquid

and control groups took the corresponding dose of Antivirus Oral Liquid simulant

3 times a day for 5 days. Disappearance rate and disappearance time of individual symptoms

clinical symptom disappearance rate and recovery time

effective cases in the treatment group for symptom clustering

and safety were observed. Results The disappearance rate of single symptom including cold

fever

cough

stuffy nose

runny nose

sore throat

aching limbs and fatigue) in the 10 ml and 20 ml test groups was significantly higher than that in the corresponding control group（P<0.05）; in addition to sweating symptoms

the disappearance rate of single symptoms in the 30 ml test group was higher than that in the 30 ml control group（P<0.05）. Clinical symptom disappearance rate was 62.0% and 44.5% respectively for the 10 ml test group and the 10 ml control group

and that was 63.0% and 42.3% respectively for the 20 ml test group and the 20 ml control group

64.8% and 39.7% for the 30 ml test group and the 30 ml control group

respectively. Differences between groups were statistically significant（P<0.01）. There was no statistical significant difference in the disappearance rate of single symptom and clinical symptom among the 10 ml

20 ml and 30 ml test groups（P>0.05）. The median disappearance time of single symptom in the 10 ml

20 ml and 30 ml test group were all within 3-4 days. Cluster analysis showed that the most suitable symptoms in the common cold symptoms were runny nose

sore throat

and cough. The incidence of adverse events was 0.46% and 0.15% in the test groups and the control groups

respectively

and there was no statistically significant difference between the groups（P>0.05）. Conclusion Antivirus Oral Liquid 10 ml

20 ml

30 ml dosage can improve the clinical symptoms of common cold

shortening the recovery time

and the recommended dosage is 10 ml

and 30 ml when the symptoms are more severe

with the method of taking 3 times a day

and the course of treatment for 4 days. It is suitable for people with runny nose

sore throat and cough symptoms.