Objective

2

To evaluate the effect of the traditional Chinese medicine （TCM） precompounded prescriptions in Shanghai in 2022 Spring on the negative nucleic acid conversion time of COVID-19 patients.

Methods

2

A retrospective analysis was performed on 145 adult asymptomatic and mild cases and 160 child mild cases who were admitted to Changxing Admission Point of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from April 1st to May 31st 2022. Data including basic information， symptoms and medication were collected. Multivariate COX regression was used to analyze the influence of related factors on the negative nucleic acid conversion rate. The difference of negative nucleic acid conversion rate between patients who took TCM formulas （adult and child treatment group） and those who did not take TCM formulas （adult and child control group） was compared and analyzed. After excluding relevant influencing factors by COX regression analysis， the nucleic acid conversion time of adult and child cases were compared.

Results

2

COX regression analysis showed that age， gender， symptom score， fever or not （only child cases）， and use of Chinese patent medicine or not had no statistical significant difference on the negative nucleic acid conversion rate in both adults and children （

P

＞0.05）. The average nucleic acid conversion time in adults group with TCM formulas was 6.80±2.57 days， which was significantly shorter than 8.52±5.27 days of the control group （

P

＜0.05）. The mean nucleic acid conversion time in the children with TCM formulas was 4.88±1.92 days， significantly shorter than 5.90±2.37 days in the control group （

P

＜0.05）.

Conclusion

2

TCM precompounded prescriptions in Shanghai in 2022 Spring

could shorten the nucleic acid negative conversion time in asymptomatic cases， and mild adults and child cases， can promote the rehabilitation of COVID-19 infection.