This paper summarized professor MA Kun's clinical experience in treating perimenopausal abnormal uterine bleeding-ovulatory-dysfunction （AUB-O） from heart and kidney. Kidney deficiency with blood stasis， and fai-lure of heart and kidney to interact are the core pathogenesis. It is proposed to supplement kidney and activate blood， restore interaction between the heart and the kidney as the basic treatment principle. According to the theory that “in urgent conditions， treat the branch， while in moderate conditions， treat the root”， it is critical to stanch bleeding and treat the branch during the bleeding period， and self-made

Yishen Zhixue Ningxin Formula

（益肾止血宁心方） is recommended to supplement kidney and calm heart， restore interaction between the heart and the kidney， boost

qi

and nourish

yin

， thereby stanching the bleeding. Thereafter， syndrome-differentiated formulas are used to prevent recurrence. In terms of deficiency of both kidney

qi

and

yin

， kidney

yang

deficiency， and kidney

yin

and

yang

deficiency，

Er Zhi Pill

with

Sheng Mai Powder

（二至丸合生脉散），

You Gui Pill

（右归丸），

Er Xian Decoction

with

Er Zhi Pill

（二仙汤合二至丸） in modifications are used， respectively. Meanwhile， it is necessary to activate blood and dissolve stasis throughout the whole treatment process.