This paper summarized Professor XU Jingfan's clinical experience of using Zisu （

Perillafrutescens

） for the treatment of spleen and stomach diseases. According to the disease characteristics， Professor XU flexibly selected the different parts of Zisu. It is believed that the leaf of Zisu is good at dispersing， dredging

qi

movement， and good at treating external contraction as well as internal damage due to depression or stagnation， and being effective in relieving abdominal lumps and fullness with vomiting； its stem is good at widering chest and diaphragm， smoothing

qi

and the middle， and dredging the twelve meridians， which can treat

qi

stagnation， especially suitable for distention and fullness in the midline of body like throat， esophagus， and stomach. Perilla seed is good at depressing

qi

and eliminating phlegm， loosening bowels to relieve constipation， which can be used in diseases of combined phlegm and

qi

， and combined treatment of lung and intestines to treat long-term constipation. In clinic， Huanglian （

Coptis chinensis

）- Zisu leaf is often used as pungent dispersing and bitter descending， promoting

qi

movement to treat persistent nausea and vomiting； Xiangfu （

Cyperi Rhizoma

）-Zisu stem is employed

as regulating

qi

to smooth the middle， soothing

qi

to disperse liver stagnation for various syndromes of

qi

stagnation； Huomaren （

Cannabis Fructus

）-Zisu seed is utilized to clear the lungs and benefit

qi

， and moisten intestines by purgation for chronic constipation. The original ancient formulas are flexibly modified and tailored， so usually modified

Banxia Houpo Decoction

（半夏厚朴汤） is used to treat plum-stone

qi

（globus hystericus） and esophageal disorders， while modified

Buzhong Yiqi Decoction

（补中益气汤） combined with

Xiangsu Powder

（香苏散） is used to treat gastroptosis， then self-prescribed

Jixing Tuxie Formula

（急性吐泻方） is used for acute diarrhea， and

Xiexie Waizhi Formula

（泄泻外治方） is applied for chronic cold-dampness diarrhea.