This paper summarized professor ZHANG Zhen's clinical experience in treating rheumatoid arthritis （RA） complicated with anemia using self-formulated

Yisui Shengxue Decoction

（益髓生血汤） with modifications. It is proposed that the core pathogenesis of this condition is rooted in spleen and kidney depletion with insufficiency of essence and blood， while pathogenic dampness obstruction and internal blood stasis accumulation are the branches. The treatment principle focuses on tonifying the spleen and kidney， replenishing essence and nourishing the marrow， and enriching and generating blood， while simultaneously removing dampness and unblocking collaterals， activating blood and dissolving stasis. Based on this approach，

Yisui Shengxue Decoction

is used as the basic prescription， with flexible modifications according to syndrome patterns and clinical manifestations. For deficiency of both

qi

and blood combined with damp turbidity syndrome， medicinals that tonify

qi

and nourish blood， fortify the spleen and eliminate dampness， and mildly

disperse obstruction are added. For wind-cold-dampness

bi

（痹） syndrome， medicinals that dispel wind and disperse cold， remove dampness and unblock the collaterals are incorporated. For wind-dampness-heat

bi

syndrome， medicinals that clear heat and eliminate dampness， unblock the collaterals and relieve

bi

are selected. For blood stasis obstructing the collaterals syndrome， medicinals that activate blood and resolve stasis， unblock the collaterals and relieve pain are combined. For

yin

deficiency with internal heat syndrome， medicinals that nourish

yin

and clear heat， cool blood and unblock the collaterals are prescribed.